Alpha-2 Macroglobulin

Non-surgical alternative treatment for Osteoarthritis.

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What is Alpha-2 Macroglobulin

Lipogems is an innovative therapy option that employs a precisely engineered device to create an injectable tissue made from your own adipose tissue reserves that can be used to provide cushioning and support as your body heals.

You may be a candidate if:


You need relief from pain and/or improvement in function


Treatment options – including physical therapy, NSAIDs, steroid injections or viscosupplement – have not provided significant relief


You suffer from an injury that limits your normal daily functioning or physical activity


You would like to explore an alternative to major surgery

How does it work?

The root cause of OA is the presence of damaging chemicals in the joints. Catabolic proteases work by degrading cartilage and damaging your joints by breaking down the cells. This causes the pain, stiffness, swelling and restricted range of motion. A2M, which is found naturally in the blood, captures these chemicals produced in the damaged joint and neutralises their degenerative effects. A2M can protect your joints and will create an environment where cartilage cells can thrive.

The Research

A significant research study out of Brown University, in collaboration with the National Institute of Health, found that a joint injection of concentrated A2M provides cartilage protection in OA by stopping the progression of arthritis.

The results of this groundbreaking study suggest that an injection of concentrated A2M may stop the breakdown of cartilage and shut down the destructive inflammatory proteins in the joint. The study also found that early intervention could be critical for minimising the development of OA. An injection of A2M during the early phase of an injury is proving to be a powerful tool in preventing progressive arthritis in the affected joints. This can be especially powerful in preventing arthritis after an ACL repair.

The Clinic

The Regenerative Orthopaedics & Sports Medicine Clinic (ROSM) on Harley Street specialises in helping people with joint problems get back to the functional level of life using non-surgical techniques. The aim is to get you back to your best without major discomfort or lengthy recovery time.

The ROSM Clinic includes a team of dedicated professionals with access to MRI, X-Ray and cutting-edge Ultrasound imaging. Patients visit from across the globe for world-class non-surgical orthopaedic care.

Dr Rogers says Regenerative Medicine treatments offer another alternative to patients who suffer from joint problems or those who are facing joint-replacement surgery. If you are seeking a minimally invasive alternative to surgery to allow you to return to your normal daily activities, a fit and active lifestyle or perhaps improve your sporting performance, Regenerative Orthopedic Medicine treatment with A2M may be the best option for you.

Expert Doctors.
Professional Care.

Dr. Ralph Rogers MD PhD MBA and CEO of RRMG is a Consultant in Regenerative Orthopedics & Sports Medicine who uses his wealth of experience to effectively tackle chronic pain and acute discomfort with innovative Regenerative Medicine treatments.

His impressive resume includes global qualifications gained at some of the finest institutions in the world. A degree in Psychology at the University of Delaware was followed by medical training at the University of Leuven in Europe, and further qualifications gained at the University of Maryland, the Free University of Brussels and the University of Leicester – including a Master’s of Science (MSc) in Musculoskeletal Ultrasound Imaging and a PhD in Exercise Physiology.

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